Prophylactic antibiotics in intra-oral bone grafting procedures: a prospective, randomized, double-blind clinical trial
이정우, 이진용, 김성민, 김명진, 이종호,
소속 상세정보
이정우 ( Lee Jung-Woo ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Surgery
이진용 ( Lee Jin-Yong ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Surgery
김성민 ( Kim Soung-Min ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Surgery
김명진 ( Kim Myung-Jin ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Surgery
이종호 ( Lee Jong-Ho ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Surgery
KMID : 0355620120380020090
Abstract
Objectives: This study was conducted in order to assess the efficacy of 1st generation cephalosporin as use as a single-dose preoperative prophylactic antibiotic for surgical wound infections resulting from intra-oral bone grafting procedures.
Materials and Methods: A total of 23 patients who were to undergo intra-oral bone graft procedures participated in this study. After randomization, 2 grams of 1st generation cephalosporin was orally administered to both the experimental and placebo groups one hour prior to surgery in a doubleblind fashion. Post-operatively, the experimental group (12 patients) was orally administered placebo three times a day for three days. The control group (11 patients) was orally administered 1st generation cephalosporin three times a day for three days. The postoperative course was observed for one month including the clinical parameters associated with infection.
Results: Postoperative infections were noted in 1 out of 11 patients in the experimental group. No infections occurred in the control group.
Conclusion: There was no significant difference in the incidence of postoperative infections between the two groups. Two grams of 1st generation cephalosporin administered orally one hour before surgery served as an effective prophylactic antibiotics therapy for intra-oral bone graft surgery.
키워드
Intra-oral bone graft; Prophylactic antibiotics; Surgical site infection
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